Theophylline is a dimethylated xanthine has been prescribed as bronchodilator, cardiotonic, diuretic and respiratory stimulant. The main objective of this work is to formulate and evaluate Theophylline bi layered floating tablets by using different hydrophilic polymers. In order to obviate the demerit of the limited residence time of the controlled release dosage form in the gastrointestinal tract and to increase the duration of release, the intra-gastric hydrodynamically balanced or floating system was conceived. Double layered tablet is attempted to incorporate the loading dose in the immediate release layer so that, the minimum effective concentration may be attained within a shorter time after which the maintenance of the level will be taken over by the drug release from the second layer. To develop the formulae and prepare the two layered intra gastric floating drug delivery system of theophylline with hydrophilic polymers such as hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (NaCMC) and methyl cellulose (MC) each alone or in combination in different drug and polymer ratios and the prepared tablet are evaluated for various physico-chemical parameters such as Hardness, Weight variation, Disintegration of first layer, Swelling thickness, Drug content, Friability, Floating time, In vitro drug release and the best formulation is compared with that of commercially available formulation of theophylline. The results show that, the type of polymer and the drug: polymer used in the tablets influences the physic-chemical characters like thickness, swelling thickness, floating time.
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